Use of this model will give us a more complete picture of the role(s) played by distinct T cell subsets in CNS autoimmunity. Particular attention is paid to a newly described transgenic mouse strain (1C6) on the NOD background whose CD4 + and CD8 + T cells are directed against the encephalitogenic peptide MOG. This is highly reminiscent of the pattern of disease observed in nearly half of MS patients. In particular, we describe EAE in non-obese diabetic (NOD) background mice, which develop a pattern of disease characterized by multiple attacks and remissions followed by a progressively worsening phase. Here, we discuss the function of CD8 + T cells in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Intriguingly, CD8 + T cells accumulate in great numbers in the CNS in progressive MS, a form of the disease that is refractory to current disease-modifying therapies that target the CD4 + T cell response. Although CD4 + T cell function in MS pathology has been extensively studied, there is also strong evidence that CD8 + T lymphocytes play a key role. Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on central nervous system (CNS) myelin.
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